In his first year at WVU, Isabelle played in three varsity games. He served as a back-up player to Ken Culbertson and Eddie Russell at left linebacker in his sophomore year in 1974. Isabelle had the ability to play linebacker, middle guard, defensive tackle or defensive end. When he was on the WVU football team, Coach Bowden said, "As Bo becomes more aggressive, his playing will increase at WVU, and he will be an outstanding player for us one of these days." Isabelle was selected all-state while attending Welch High School.